21st International Conference on Data Engineering Workshops (ICDEW'05)
Prediction of Protein Functions Based on Protein-Protein Interaction Networks: A Min-Cut Approach
Tokyo, Japan
April 05-April 08
ISBN: 0-7695-2657-8
Toshihiro Koma, Nara Institute of Science and Technology (NAIST), Japan
Ken Kurokawa, Nara Institute of Science and Technology (NAIST), Japan
This paper presents an approach for prediction of protein functions based on protein-protein interaction networks. For the purpose of prediction, we not only consider the interactions of functionunknown proteins with function-known proteins but also the interactions of function-unknown proteins with function-unknown proteins. Prediction is performed in the context of the entire network. This is a min-cut approach because we try to assign function-unknown proteins to different functional groups in such a way so that the number of intergroup interactions becomes the minimum in the whole network. Also, we show some evaluation results by applying the proposed method to yeast Saccharomyces cerevisiae protein-protein interaction network. However, this is a general method and can be applied to other organisms alike.
Index Terms:
protein function prediction, protein-protein interaction network, min-cut, heuristic method.
Citation:
Md. Altaf-Ul-Amin, Toshihiro Koma, Ken Kurokawa, Shigehiko Kanaya, "Prediction of Protein Functions Based on Protein-Protein Interaction Networks: A Min-Cut Approach," icdew, pp.1156, 21st International Conference on Data Engineering Workshops (ICDEW'05), 2005