In typical distributed environments, there are two parties: consumers and providers. Consumers have computational jobs while may lack of computational resources. Providers have relatively underutilized resources. With the rapid advancement in high-speed networks, how to enable the effective and secure interaction between consumers and providers has become increasingly important. Because of the distributed ownership of resources, however, it is a very challenging problem. We propose the TruGrid, a Self-sustaining Trustworthy Grid, to solve it. The TruGrid is a novel loosely connected grid system, which guarantees the incentive of every participant and therefore it is a self-sustaining system. We also identify two security challenges arising in the TruGrid, i.e., free-rider and boaster. The proposed trustworthiness management and the penalty model successfully overcome the challenges. Simulation results demonstrate that the TruGrid is a promising actuator to enable the interaction between autonomous consumers and providers.