A new information-theoretic approach is presented for finding the pose of an object in an image. The technique does not require information about the surface properties of the object, besides its shape, and is robust with respect to variations of illumination. In our derivation, few assumptions are made about the nature of the imaging process. As a result, the algorithms are quite general and can foreseeably be used in a wide variety of imaging situations. Experiments are presented that demonstrate the approach in registering magnetic resonance images, aligning a complex 3D object model to real scenes including clutter and occlusion, tracking a human head in a video sequence and aligning a view-based 2D object model to real images. The method is based on a formulation of the mutual information between the model and the image. As applied in this paper, the technique is intensity-based, rather than feature-based. It works well in domains where edge or gradient-magnitude based methods have difficulty, yet it is more robust then traditional correlation. Additionally, it has an efficient implementation that is based on stochastic approximation.