The adaptation and robust sensing capabilities of living organisms remains envy to engineers. Numerous research efforts have been started to mimic these capabilities of living beings such as self-configuration, self-diagnosis and self-healing etc., and exploit them in technical devices, systems, and appliances. Ubiquitous embedded systems comprises of indispensable analog and mixed-signal component for sensor and actuator interfacing. The regarded sensor electronics are vulnerable to numerous static and dynamic influences, mismatches and to substrate noise. Specific generic cells for sensor amplifiers and analog/mixed-signal arrays are regarded in our work, which can be configured and changed/repaired under the control of an optimisation technique based on swarm intelligence. The approach targets on yielding fast, flexible, adaptive HW/SW platform supporting rapid prototyping and maintaining quality. The first chip design of a reconfigurable sensor signal amplifier has been tested by extrinsically generated PSO based configurations. The embedded system architecture and the measured results will be presented and an outlook on intrinsic system design will be given.