A virtual organization is a temporary network of companies, which implies the potential opportunity to learn and share abundant sources of complementary and compatible knowledge possessed by members. Learning in a virtual organization is the key to achieve agility of a virtual organization; however, few studies are focused on this dimension. Therefore, this research attempts to bring insights of learning in a virtual organization by developing a framework of transactive networks system including five software components as matchmaking manager, skills-based manager, contribution manager, context manager, and social network manager. With the proposed multiagent-based system, this study illustrates how it can be of help to connect both knowledge requesters and appropriate knowledge contributors to augment and retain the social networks in fostering virtual organizational learning. The contributions of this research can be viewed in two dimensions: knowledge management technologies, and knowledge sharing and learning in virtual organizations.