This study empirically investigated what knowledge topics are important to an information system (IS) professional from an industrial perspective. More than 200 IS professionals participated in this study to provide what they thought about 43 IS related professional courses. The respondents were asked to rate the knowledge level that they had learned about each of the course in their formal education, are now familiar with about it as well as how practical the topic will be in their career. The findings might be helpful to IS training institutes, licensing bodies, departments and curriculum designers in universities or colleges. The results of this study can provide useful suggestions to help IS professionals for choosing the suitable and right learning courses as well as to act as practicable guidelines for IS professional curriculum planning and development.