Recently, grid computing related researches have flourished in China. e-Science, which aims to create an enabling grid-based infrastructure appropriate for the science drivers, also has gradually played an important role in scientific communities. Initially, e-Science was always interlaced with grid directly, which resulted in the maintenance of e-Science applications involved in embarrassment. Therefore, the need for legible and distinguishable implications of them becomes widely aware. We have proposed a novel architecture, which emphasizes the notion of deploying e-Science on grid, not to develop e-Science with grid directly. In this paper, we present a preliminary specification, called ADIF, which is the extensibility of our previous work, primarily discussing the details of its resource management, workflow management and virtual team management in e-Science application-level. We also provide a prototype system of the collaborative work environment, which can facilitate scientists taking advantage of e-Science more usably. Last, an exemplary e-Science application scenario in chemistry will be demonstrated.