Signaling Networks Involved in Retinal Degeneration in Mice

	This Article
	Subscribers, please Login Purchase article: $19 PDF RSS feed
	Share
	Email this Article to a friend
	Bibliographic References
	ASCII Text BibTex RefWorks Procite/RefMan/Endnote
	Add to:
	Digg Furl Spurl Blink Simpy Google Del.icio.us Y!MyWeb
	Search
	Similar Articles Articles by Jayalakshmi Krishnan Articles by Gwang Lee Articles by Sang-Uk Han Articles by Sangdun Choi

2007 Frontiers in the Convergence of Bioscience and Information Technologies

Jeju Island, Korea

October 11-October 13

ISBN: 978-0-7695-2999-8

	ASCII Text	x
	Jayalakshmi Krishnan, Gwang Lee, Sang-Uk Han, Sangdun Choi, "Signaling Networks Involved in Retinal Degeneration in Mice," Frontiers in the Convergence of Bioscience and Information Technologies, pp. 3-6, 2007 Frontiers in the Convergence of Bioscience and Information Technologies, 2007.

	BibTex	x
	@article{ 10.1109/FBIT.2007.116, author = {Jayalakshmi Krishnan and Gwang Lee and Sang-Uk Han and Sangdun Choi}, title = {Signaling Networks Involved in Retinal Degeneration in Mice}, journal ={Frontiers in the Convergence of Bioscience and Information Technologies}, volume = {0}, year = {2007}, isbn = {978-0-7695-2999-8}, pages = {3-6}, doi = {http://doi.ieeecomputersociety.org/10.1109/FBIT.2007.116}, publisher = {IEEE Computer Society}, address = {Los Alamitos, CA, USA}, }

	RefWorks Procite/RefMan/Endnote	x
	TY - CONF JO - Frontiers in the Convergence of Bioscience and Information Technologies TI - Signaling Networks Involved in Retinal Degeneration in Mice SN - 978-0-7695-2999-8 SP3 EP6 A1 - Jayalakshmi Krishnan, A1 - Gwang Lee, A1 - Sang-Uk Han, A1 - Sangdun Choi, PY - 2007 VL - 0 JA - Frontiers in the Convergence of Bioscience and Information Technologies ER -

DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/FBIT.2007.116

Knockout mouse forms a great tool in identifying the perturbations in signaling networks. Retinal degeneration and signaling networks involved in it have long been an intriguing question. We ventured out in finding the networks by using rhodopsin kinase (Rhok-/-) or arrestin (Sag-/-) knockout and as well as both the knockouts in mice retina. Our screening analysis revealed that during initial exposure to light many apoptosis inducing transcription factors like p53, ATF4, c-FOS and GADD45 beta up-regulated but later phase of degeneration was accompanied by NF-B and AP1 expression.

Citation:

Jayalakshmi Krishnan, Gwang Lee, Sang-Uk Han, Sangdun Choi, "Signaling Networks Involved in Retinal Degeneration in Mice," fbit, pp.3-6, 2007 Frontiers in the Convergence of Bioscience and Information Technologies, 2007

Peer Review Notice | Give Us Feedback

Usage of this product signifies your acceptance of the Terms of Use.