In this paper, a model that combines knowledge management and quality management approaches is presented. Essential concepts are provided about what must be considered in establishing a quality system for an institution, company or group that is dedicated to Research and Development (R&D) activities and that needs to fulfill the ISO9001: 2000 standard to obtain certification. The paper describes how certain principles of knowledge management and the requirements of the ISO9001 standard can be aligned with the objectives of an R&D organization and what aspects should be considered in fulfilling the standard. The model and the comments provided will help to an R&D organization to become ISO9001 certified with a minimum of additional effort as compared with its operation without adhering to the standard.