This paper presents the architecture and user interface of a generic framework supporting collaboration in virtual enterprises. It is intended to provide users with an intuitive interface methodology which is independent from the underlying CSCW components like application sharing, audio/video and file transfer. The user interface relies on a room metaphor with simple drag & drop or clicking actions for carrying out functions like conference initiation, invitation, file transfer or application sharing. The architecture provides a replicated data model to give users awareness of any modification in the virtual enterprise. The system supports synchronous, asynchronous, and autonomous collaboration. A field study shows the usefulness of the described CSCW framework.