Informatics in biomedicine is becoming increasingly interconnected via distributed information services, interdisciplinary correlation, and crossinstitutional collaboration. Partnering with NASA, the Early Detection Research Network (EDRN), a program managed by the National Cancer Institute, has been defining and building an informatics architecture to support the discovery of biomarkers in their earliest stages. The architecture established by EDRN serves as a blueprint for constructing a set of services focused on the capture, processing, management and distribution of information through the phases of biomarker discovery and validation.