With the proliferation of Grid computing, potentially vast computational resources are available for solving complex problems in science and engineering. However, writing, deploying, and testing e-Science applications over highly heterogeneous and distributed infrastructure are complex and error prone. Further complicating matters, programmers may need to target a variety of different Grid middleware packages. This paper presents the design and implementation of Worqbench, an integrated, modular and middleware neutral framework for e- Science application development on the Grid. Worqbench can be incorporated into a number of existing Integrated Development Environments, further leveraging the advantages of such systems. We illustrate one such implementation in the Eclipse environment.