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First International Conference on e-Science and Grid Computing (e-Science'05)
Development of New Method of Primer Design Based on Genomewide for SNP Typing under Problem Solving Environment on Grid
Melbourne, Australia
December 05-December 08
ISBN: 0-7695-2448-6
ASCII Text
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Takashige Oroguchi, Tomofumi Inoue, Isao Tomabechi, Yoshio Tago, Toru Makino, "Development of New Method of Primer Design Based on Genomewide for SNP Typing under Problem Solving Environment on Grid," e-Science and Grid Computing, International Conference on, pp. 516-521, First International Conference on e-Science and Grid Computing (e-Science'05), 2005.
 
 
BibTex
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@article{ 10.1109/E-SCIENCE.2005.31,
author = {Takashige Oroguchi and Tomofumi Inoue and Isao Tomabechi and Yoshio Tago and Toru Makino},
title = {Development of New Method of Primer Design Based on Genomewide for SNP Typing under Problem Solving Environment on Grid},
journal ={e-Science and Grid Computing, International Conference on},
volume = {0},
year = {2005},
isbn = {0-7695-2448-6},
pages = {516-521},
doi = {http://doi.ieeecomputersociety.org/10.1109/E-SCIENCE.2005.31},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - e-Science and Grid Computing, International Conference on
TI - Development of New Method of Primer Design Based on Genomewide for SNP Typing under Problem Solving Environment on Grid
SN - 0-7695-2448-6
SP516
EP521
A1 - Takashige Oroguchi,
A1 - Tomofumi Inoue,
A1 - Isao Tomabechi,
A1 - Yoshio Tago,
A1 - Toru Makino,
PY - 2005
KW - null
VL - 0
JA - e-Science and Grid Computing, International Conference on
ER -
 
Takashige Oroguchi, Kanazawa University
Tomofumi Inoue, Kanazawa University
Isao Tomabechi, NovusGene Inc.
Yoshio Tago, Kanazawa University
Toru Makino, NovusGene Inc.
How primers are specific to target base sequences containing Single Nucleotide Polymorphism (SNP) is considered as the key to SNP analysis. In this study, we have attempted to develop high-accuracy primer design. For that purpose, we have developed problem solving environment (PSE) on grid system and established an environment to execute Basic Local Alignment Search Tool (BLAST) genome-widely. We have applied this primer design system in the PSE to drug-metabolizing enzyme and verified that this new design method generated highly accurate primers compared with the existing methods by means of computation and experiment. We have also developed a workflow system for the PSE on the grid system and achieved remarkable improvement in efficiency of the primer design. The new method have achieved more than 10 times efficiency compared with the existing methods.
Citation:
Takashige Oroguchi, Tomofumi Inoue, Isao Tomabechi, Yoshio Tago, Toru Makino, "Development of New Method of Primer Design Based on Genomewide for SNP Typing under Problem Solving Environment on Grid," e-science, pp.516-521, First International Conference on e-Science and Grid Computing (e-Science'05), 2005
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