Recently, there have been demands for greater functional diversity and higher performance in the information technology infrastructure. As a result, the complexity and scale of product design in the product development phase have increased. In addition, development periods need to be reduced so products can be marketed sooner. These requirements have rapidly increased the need to simulate and analyze efficiently in order to achieve optimum designs and verification. At the same time, the needs to do massive simulations effectively become large to avoid the risks in financial business. To satisfy these requirements, there are some technical issues to be solved. For this purpose, CyberGRIP has been developed as grid problem solving environments to realize the virtualization of heterogeneous distributed computing resources. This paper describes the detail explanation of CyberGRIP, its concrete applications and results for the product development in manufacturing industries and for the currency option in financial business.