While design processes in certain domains have shifted towards early adoption of simulation and virtualisation techniques, processes??monitoring and reuse is not well-integrated into current development??practices. We introduce a framework to integrate Multidisciplinary Design Optimisation processes using ontological engineering, where artefact and simulation models are exploited to yield more effective optimisation-driven development. We show how meta-modelling techniques can overcome representational and semantic differences between analysis??disciplines and execution environments.