System-level design has a disadvantage in not knowing important aspects about the final layout. This is critical for SoC, where uncertainties in communication delay by very deep submicron effects cannot be neglected. This paper presents a layout-aware bus architecture (BA) synthesis algorithm for designing the communication sub-system of an SoC. BA synthesis includes finding bus topology and routing individual buses, so that constraints like area, bus speed and length, are tackled at the physical level. The paper presents the BA automatically synthesized for a network processor and a JPEG SoC.