The paper exploits the interlayer coupling of across-layer design concept in grid computing environment. A joint application and fabric layer resource scheduling algorithm which combines both application-centric and system-centric scheduling benefits is proposed. We formulate the integrated design of resource allocation and user QoS satisfaction control into a constrained optimization problem. The application layer adaptively adjusts user' sresource demand based on the current resource conditions, while the fabric layer adaptively allocates CPU, storage and bandwidth required by the upper layer.