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2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05)
Identifying Local Gene Expression Patterns in Biomolecular Networks
Stanford, California
August 08-August 11
ISBN: 0-7695-2442-7
A. Y. Sivachenko, Ariadne Genomics, Inc.
A. Yuryev, Ariadne Genomics, Inc.
N. Daraselia, Ariadne Genomics, Inc.
I. Mazo, Ariadne Genomics, Inc.

This study is aimed at elucidating putative transcription regulators TRs responsible for the observed differential expression pattern. Combined direct promoter binding and indirect transcriptional regulation networks were used, and the expression levels of each TR?s downstream targets were collectively analyzed, as a sample, for significance. Statistical procedure was also developed that takes into account the sign of the expression change, thus requiring the downstream targets to exhibit expression pattern consistent with the regulatory relationship effect signs.

Citation:
A. Y. Sivachenko, A. Yuryev, N. Daraselia, I. Mazo, "Identifying Local Gene Expression Patterns in Biomolecular Networks," csbw, pp.180-184, 2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05), 2005
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