loading...
 This Article 
   
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05)
Biological Pathway Prediction from Multiple Data Sources Using Iterative Bayesian Updating
Stanford, California
August 08-August 11
ISBN: 0-7695-2442-7
Corey Powell, University of California, Santa Cruz
Joshua Stuart, University of California, Santa Cruz

There is a diversity of functional genomics data, such as gene expression data from microarray experiments, phenotypic data from gene deletion experiments, protein-protein interaction data, and data from manually curated databases of gene function. Each data source finds certain types of relationships between genes and misses other types of relationships. A method that can combine multiple data sources might then be able to uncover more relationships than a method that depends on a single data source. This paper presents a method that uses an iterative Bayesian updating technique to combine data from multiple sources, represented as undirected weighted graphs, in order to estimate the probability that a gene is part of a given biological pathway. This method improves performance over a simple neighbor based approach for several well characterized biological pathways.

Citation:
Corey Powell, Joshua Stuart, "Biological Pathway Prediction from Multiple Data Sources Using Iterative Bayesian Updating," csbw, pp.159-160, 2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05), 2005
Usage of this product signifies your acceptance of the Terms of Use.