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2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05)
Visualization of Logic Analysis of Phylogenetic Profiles (LAPP)
Stanford, California
August 08-August 11
ISBN: 0-7695-2442-7
Kay A. Robbins, Cajal Neuroscience Research Institute University of Texas at San Antonio
Li Zhao, Department of Computer Science, University of Texas at San Antonio

Recently Bowers et al. [1] analyzed triplet logic relationships among 4873 Clusters of Orthologous Groups (COGS) from 67 fully sequenced organisms by calculating how well logic relationships between proteins a and b predicted the presence or absence of protein c (the uncertainty). The log of the normalized uncertainty distribution follows an approximately linear relationship for uncertainties in the interval [0.1, 0.9]. Using fitted parameters of this relationship as a characterization, we develop four types of visual analysis for LAPP data: distributions of uncertainty over logical relation type, distributions of uncertainty over functional categories, relationships of uncertainty of the overall population to known network relationships of a particular organism, and relationships of uncertainty distributions to groups obtained by standard clustering techniques. The purpose of this study is two-fold: to better understand the implications of uncertainty predictions for automatic protein network generation and to create new visualization tools for looking at this type of data.

Citation:
Kay A. Robbins, Li Zhao, "Visualization of Logic Analysis of Phylogenetic Profiles (LAPP)," csbw, pp.275-276, 2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05), 2005
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