Safeguarding patients’ private information is one of the most challenging issues in the design and implementation of modern e-Health systems. Recent advances in Hippocratic Databases (HDB) show a promising direction towards the enforcement of privacy policies in e-Health systems. This paper tackles issues in applying the HDB design to e-Health systems. More specifically, we design an architecture for integrating APPEL preferences with HDB; we extend the original HDB design to support fine-grained privacy authorizations demanded by patients; we adapt the design to a multi-dimensional model; we also propose a design for hierarchical authorizations. Finally, we discuss implementation issues and justify our designs with experimental results.