Patching technologies are commonly applied to improve the dependability of software after release. This paper proposes an autonomous hot patching (AHP) framework to fully automate the reasoning for the causes of failures, and to patch the binary code of Web-based applications. AHP admits the hardness for rooting out all faults before product release, and autonomously patches problems of application programs. By directly operating on binary code, AHP is universal to virtually all applications. A promising application of AHP is to shortcut the remote maintenance center (RMC) and hence to reduce the turn around time for patches.