The Physiome Project of the International Union of Physiological Sciences (IUPS) is attempting to provide a comprehensive framework for modelling the physiology of the human body using multi-scale computational methods which can incorporate the biochemistry, biophysics and anatomy of cells, tissues and organs. A major goal of the project is to use computational modelling to analyse integrative biological function in terms of underlying structure and molecular mechanisms. It is an internationally collaborative open-source project that is providing a public domain framework for computational physiology, including the development of modeling standards, computational tools and web-accessible databases of models of structure and function at all spatial scales [1-4]. It aims to develop an infrastructure for linking models of biological structure and function across multiple levels of spatial organization and multiple time scales.