The lack of widely accepted standards and the use of different middleware solutions divide today’s Grid resources into non-interoperable production Grid islands. On the other hand, more and more experiments require such a large number of resources that the interoperation of existing production Grids becomes inevitable. This paper, based on the current results of grid interoperation studies, defines generic requirements towards the workflow level interoperation of grid solutions. It concentrates on intra-workflow interoperation of grid data resources, as one of the key areas of generic interoperation, and describes through an example how existing tools can be extended to achieve the required level of interoperation.