We discuss the use of glove-driven interface in radiological workstations and present a prototype that aims to integrate common functions such as virtual manipulation and navigation control, with a basic gesture interface. The fast rate of and numerical data acquired by glove-driven interfaces, allows a much broader set of functionalities to be implemented in a highly demanding tridimensional visualization application. The prototype provides the basic gesture interface using a 5DT DataGlove5 Ultra and a Flock of Birds tracker, combining independent hand posture and trajectory recognition to send command messages to the host application. Using a synchronized state machine in the host application and the prototype, the gestures can activate special menus, and call up specific function or screens.