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19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06)
Identifying a Central Nervous System Perturbation that Explains Peripheral Hypocortisolism by Modeling the HPA Axis
Salt Lake City, Utah
June 22-June 23
ISBN: 0-7695-2517-1
ASCII Text
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Shakti Gupta, Eric Aslakson, Suzanne D. Vernon, "Identifying a Central Nervous System Perturbation that Explains Peripheral Hypocortisolism by Modeling the HPA Axis," Computer-Based Medical Systems, IEEE Symposium on, pp. 550-554, 19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06), 2006.
 
 
BibTex
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@article{ 10.1109/CBMS.2006.96,
author = {Shakti Gupta and Eric Aslakson and Suzanne D. Vernon},
title = {Identifying a Central Nervous System Perturbation that Explains Peripheral Hypocortisolism by Modeling the HPA Axis},
journal ={Computer-Based Medical Systems, IEEE Symposium on},
volume = {0},
year = {2006},
issn = {1063-7125},
pages = {550-554},
doi = {http://doi.ieeecomputersociety.org/10.1109/CBMS.2006.96},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - Computer-Based Medical Systems, IEEE Symposium on
TI - Identifying a Central Nervous System Perturbation that Explains Peripheral Hypocortisolism by Modeling the HPA Axis
SN - 1063-7125
SP550
EP554
A1 - Shakti Gupta,
A1 - Eric Aslakson,
A1 - Suzanne D. Vernon,
PY - 2006
KW - null
VL - 0
JA - Computer-Based Medical Systems, IEEE Symposium on
ER -
 
Shakti Gupta, Centers for Disease Control and Prevention, USA
Eric Aslakson, Centers for Disease Control and Prevention, USA
Suzanne D. Vernon, Centers for Disease Control and Prevention, USA
The hypothalamus- pituitary- adrenal is the body?s main stress management system, which responds to any threat to homeostasis or internal environmental balance of the body by controlling the body?s cortisol level. Dysregulation of the HPA axis is involved in numerous stress-related diseases including posttraumatic stress disorder and chronic fatigue syndrome. We present a new structured model that includes the glucocorticoid receptor that produces bistability in the HPA axis steady state. Small stresses do not perturb the system, but large stresses force the system to an alternate steady state. This bistable state can describe hypocortisolism, which is observed in these stress-related illnesses.
Citation:
Shakti Gupta, Eric Aslakson, Suzanne D. Vernon, "Identifying a Central Nervous System Perturbation that Explains Peripheral Hypocortisolism by Modeling the HPA Axis," cbms, pp.550-554, 19th IEEE Symposium on Computer-Based Medical Systems (CBMS'06), 2006
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