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14th IEEE Symposium on Computer-Based Medical Systems (CMBS'01)
Hidden Markov Models for Chromosome Identification
Bethesda, Maryland
March 26-March 27
ISBN: 0-7695-1004-3
John M. Conroy, Institute for Defense Analyses
Robert L. Becker Jr, Armed Forces Institute of Pathology
William Lefkowitz, Armed Forces Institute of Pathology
Kewi L. Christopher, Armed Forces Institute of Pathology
Rawatmal B. Surana, Armed Forces Institute of Pathology
Timothy J. O'Leary, Armed Forces Institute of Pathology
Dianne P. O'Leary, University of Maryland
Tamara G. Kolda, Sandia National Laboratories
Abstract: In this talk we present a Hidden Markov Markov for automatic karyotyping. Previously, we demonstrated that this method is robust in the presence of different types of metaphase spreads, truncation of chromosomes, and minor chromosome abnormalities, and that it gives results superior to neural network on standard data sets. In this work we evaluate it on a data set consisting of a mix of chromosomes obtained from blood, amniotic fluid and bone marrow specimens. The method is shown to be robust on this mixed set of data as well as giving far superior results than that obtained by neural networks.Technical areas: Signal and image processing in medicine; software systems in medicine.
Citation:
John M. Conroy, Robert L. Becker Jr, William Lefkowitz, Kewi L. Christopher, Rawatmal B. Surana, Timothy J. O'Leary, Dianne P. O'Leary, Tamara G. Kolda, "Hidden Markov Models for Chromosome Identification," cbms, pp.0473, 14th IEEE Symposium on Computer-Based Medical Systems (CMBS'01), 2001
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