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2008 International Conference on BioMedical Engineering and Informatics
Absolute Quantification of Swine Brain Glutamate Compounds Concentration using MR Spectroscopy and LCModel after Nasal Spraying Butorphanol Tartrate
May 27-May 30
ISBN: 978-0-7695-3118-2
ASCII Text
x 
 
J.L. Wu, T. Liu, Y. Lin, Z.W. Shen, Y.W. Miao, R.H. Wu, Z.J. Lang, "Absolute Quantification of Swine Brain Glutamate Compounds Concentration using MR Spectroscopy and LCModel after Nasal Spraying Butorphanol Tartrate," BioMedical Engineering and Informatics, International Conference on, vol. 2, pp. 348-352, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
BibTex
x
 
@article{ 10.1109/BMEI.2008.96,
author = {J.L. Wu and T. Liu and Y. Lin and Z.W. Shen and Y.W. Miao and R.H. Wu and Z.J. Lang},
title = {Absolute Quantification of Swine Brain Glutamate Compounds Concentration using MR Spectroscopy and LCModel after Nasal Spraying Butorphanol Tartrate},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {2},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {348-352},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.96},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - Absolute Quantification of Swine Brain Glutamate Compounds Concentration using MR Spectroscopy and LCModel after Nasal Spraying Butorphanol Tartrate
SN - 978-0-7695-3118-2
SP348
EP352
A1 - J.L. Wu,
A1 - T. Liu,
A1 - Y. Lin,
A1 - Z.W. Shen,
A1 - Y.W. Miao,
A1 - R.H. Wu,
A1 - Z.J. Lang,
PY - 2008
KW - null
VL - 2
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
The purpose of this study was to investigate whether the Central Nervous System (CNS) analgesics affect the metabolites of swine brain by nasal spraying. Single voxel proton magnetic resonance spectroscopy (1H-MRS) was performed on 9 swine. The data were post-processed using LCModel software. Before nasal spraying butorphanol tartrate, the mean Glutamate compounds (Glx) concentration was 9.276?0.542 mmol/kg. After nasal spraying, the mean Glx concentration was 7.283?0.540mmol/kg. Using paired sample t-test we found that swine brain Glx level was significantly decreased after using nasal spray analgesic (t=2.826, p=0.022). However, there were no significant differences concerning mean NAA concentrations and mean Choline (Cho) concentrations before and after nasal spraying. Before nasal spraying, the mean NAA and Cho concentrations were 6.094?0.384 mmol/kg and 1.547?0.114 mmol/kg, respectively. After nasal spraying, the mean NAA and Cho concentrations were 5.530?0.346mmol/kg and 1.255?0.079mmol/kg, respectively. Our results imply that Glx are nociceptive neurotransmitters and play an important role in the analgesia.
Citation:
J.L. Wu, T. Liu, Y. Lin, Z.W. Shen, Y.W. Miao, R.H. Wu, Z.J. Lang, "Absolute Quantification of Swine Brain Glutamate Compounds Concentration using MR Spectroscopy and LCModel after Nasal Spraying Butorphanol Tartrate," bmei, vol. 2, pp.348-352, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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