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2008 International Conference on BioMedical Engineering and Informatics
Using Random Perturbation Method to Improve Efficacy Prediction of siRNA Sequences
May 27-May 30
ISBN: 978-0-7695-3118-2
ASCII Text
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Willard Frutiger, Jeremy Collins, Wei Hu, "Using Random Perturbation Method to Improve Efficacy Prediction of siRNA Sequences," BioMedical Engineering and Informatics, International Conference on, vol. 1, pp. 194-199, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
BibTex
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@article{ 10.1109/BMEI.2008.8,
author = {Willard Frutiger and Jeremy Collins and Wei Hu},
title = {Using Random Perturbation Method to Improve Efficacy Prediction of siRNA Sequences},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {1},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {194-199},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.8},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - Using Random Perturbation Method to Improve Efficacy Prediction of siRNA Sequences
SN - 978-0-7695-3118-2
SP194
EP199
A1 - Willard Frutiger,
A1 - Jeremy Collins,
A1 - Wei Hu,
PY - 2008
KW - siRNA
KW - random perturbation
KW - linear model
VL - 1
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
Short interfering RNAs (siRNAs) can be used to silence gene expression. The potential application of this research opens the door for the development of the future generations of effective drugs. The question ofhow to design effective siRNAs is still under intense study. Our motivation is to improve the accuracy of the simple linear model. We propose a new random perturbation method that predicts most actives iRNA candidates with high accuracy. The contribution of this paper is two-fold. First, we developed the random perturbation method which improved the prediction of siRNA sequence efficacy. Our method is easy to implement and runs efficiently. Second, we developed a new method; we named it alpha method that can linearly optimize different contributions from different weight sets.
Index Terms:
siRNA, random perturbation, linear model
Citation:
Willard Frutiger, Jeremy Collins, Wei Hu, "Using Random Perturbation Method to Improve Efficacy Prediction of siRNA Sequences," bmei, vol. 1, pp.194-199, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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