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2008 International Conference on BioMedical Engineering and Informatics
Senescence-Associated ?-Galactosidase as a Senescence Biomarker Showed in Rat Hippocampus
May 27-May 30
ISBN: 978-0-7695-3118-2
ASCII Text
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Y.Q. Geng, J.T. Guan, B.H. Wang, X.H. Xu, Y.C. Fu, "Senescence-Associated ?-Galactosidase as a Senescence Biomarker Showed in Rat Hippocampus," BioMedical Engineering and Informatics, International Conference on, vol. 1, pp. 173-177, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
BibTex
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@article{ 10.1109/BMEI.2008.37,
author = {Y.Q. Geng and J.T. Guan and B.H. Wang and X.H. Xu and Y.C. Fu},
title = {Senescence-Associated ?-Galactosidase as a Senescence Biomarker Showed in Rat Hippocampus},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {1},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {173-177},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.37},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
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TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - Senescence-Associated ?-Galactosidase as a Senescence Biomarker Showed in Rat Hippocampus
SN - 978-0-7695-3118-2
SP173
EP177
A1 - Y.Q. Geng,
A1 - J.T. Guan,
A1 - B.H. Wang,
A1 - X.H. Xu,
A1 - Y.C. Fu,
PY - 2008
KW - senescence associated ?-galactosidase; hippocampus; rat; biomarker
VL - 1
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
Objective: To investigated the activity of SA-?-GAL in rat hippocampus at different ages. Method: Hippocampus of 6, 18 and 24 month-age rats were observed by histochemical staining for SA-?-GAL and cytochemical staining for SA-?-GAL on prolong cultured hippocampal neurons. Results: SA-?-GAL activity elevated in hippocampal pyramidal cells of CA3 region with advanced age. The upregulated SA-?-GAL activity was accompanied by an increase prolong period of cultured hippocampal neurons. Interestingly, the staining of SA-?-GAL was strikingly low in dentate gyrus, where the granules cells neurogenesis of rat from 6 to 18 and 24 month-age. Conclusion: These results suggested that SA-?-GAL showed the senescent neurons in hippocampus, moreover, SA-?-GAL is probably a potential tool to detect the neurogenesis pool in adult brain.
Index Terms:
senescence associated ?-galactosidase; hippocampus; rat; biomarker
Citation:
Y.Q. Geng, J.T. Guan, B.H. Wang, X.H. Xu, Y.C. Fu, "Senescence-Associated ?-Galactosidase as a Senescence Biomarker Showed in Rat Hippocampus," bmei, vol. 1, pp.173-177, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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