Illustrative visualization of complex vasculature hasbeen one of the indispensable components in medical educationand training. In this paper, we propose a rendering pipeline which incorporates various perception-aware techniques for informative vascular illustration. Chromostereopsis rendering, isophote-based line hatching, and enhanced silhouette drawing have been integrated seamlessly through multiple shader passes. With advanced GPU acceleration techniques including render to texture (RTT), framebuffer object (FBO) and fast image convolution, areal-time frame-rate can be achieved.