2008 International Conference on BioMedical Engineering and Informatics A Tool for Finding Possible Explanation for Adverse Drug Reactions Through Drug and Drug Target Interactions May 27-May 30 ISBN: 978-0-7695-3118-2
DOI Bookmark: http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.26
Adverse drug reaction (ADR) is big challenge in drug development process. The US Food and Drug Administration (FDA) collects a lot of ADR report cases. We develop a tool which integrates drug and drug target knowledge bases and builds up drug target networks whose topological analysis can reveal drug interaction complexity for every ADR report in FDA. We classify drugs using Anatomical Therapeutic Chemical Classification (ATC) code and drug targets using Drug Target Ontology (DTO). This tool can help not only the analysis and prediction on ADRs cases but also the drug target assessment in the early drug discovery process.
Index Terms:
Adverse Drug Reaction, Drug Target Ontology, Drug Target Network, Clustering Coefficient
Citation:
Shih-Fang Lin, Ke-Ting Xiao, Yu-Ting Huang, Von-Wun Soo, "A Tool for Finding Possible Explanation for Adverse Drug Reactions Through Drug and Drug Target Interactions," bmei, vol. 1, pp.580-584, 2008 International Conference on BioMedical Engineering and Informatics, 2008 Usage of this product signifies your acceptance of the Terms of Use. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb