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2008 International Conference on BioMedical Engineering and Informatics
Genome-Scale Simulation Analysis: The Impact of Gene Deletion on the Metabolic Flux of E.coli and Its Flux-backbone
May 27-May 30
ISBN: 978-0-7695-3118-2
ASCII Text
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Xu Zixiang, Xie Jianming, Yang Xinan, Sun Xiao, "Genome-Scale Simulation Analysis: The Impact of Gene Deletion on the Metabolic Flux of E.coli and Its Flux-backbone," BioMedical Engineering and Informatics, International Conference on, vol. 1, pp. 695-699, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
BibTex
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@article{ 10.1109/BMEI.2008.259,
author = {Xu Zixiang and Xie Jianming and Yang Xinan and Sun Xiao},
title = {Genome-Scale Simulation Analysis: The Impact of Gene Deletion on the Metabolic Flux of E.coli and Its Flux-backbone},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {1},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {695-699},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.259},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - Genome-Scale Simulation Analysis: The Impact of Gene Deletion on the Metabolic Flux of E.coli and Its Flux-backbone
SN - 978-0-7695-3118-2
SP695
EP699
A1 - Xu Zixiang,
A1 - Xie Jianming,
A1 - Yang Xinan,
A1 - Sun Xiao,
PY - 2008
KW - null
VL - 1
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
Based on the gene-protein-reaction (GPR) model of E.coli_iAF1260 and the method of constraint-based analysis, we first calculated the metabolic flux distribution of E.coli_iAF1260 and defined three types of key genes (genes related to many reactions, genes related to high flux reactions, genes related to the hubs of correlated reaction sets) which related to its metabolism. Then we analyzed the impact of key gene deletion on the metabolic flux redistribution of E.coli_iAF1260 and on its high-flux backbone (HFB). We find that the deletion of these key genes will greatly affect the metabolic flux distribution but will affect flux backbone trivially. Because the in silico model of E.coli_iAF1260 is tested by many experiments, thus is credible, we can conclude that the result we get has biological significances.
Citation:
Xu Zixiang, Xie Jianming, Yang Xinan, Sun Xiao, "Genome-Scale Simulation Analysis: The Impact of Gene Deletion on the Metabolic Flux of E.coli and Its Flux-backbone," bmei, vol. 1, pp.695-699, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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