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2008 International Conference on BioMedical Engineering and Informatics
On Single-Array Genotype Calling Algorithms
May 27-May 30
ISBN: 978-0-7695-3118-2
ASCII Text
x 
 
Anna Tikhomirov, Anuar Konkashbaev, Dan L. Nicolae, "On Single-Array Genotype Calling Algorithms," BioMedical Engineering and Informatics, International Conference on, vol. 1, pp. 459-462, 2008 International Conference on BioMedical Engineering and Informatics, 2008.
 
 
BibTex
x
 
@article{ 10.1109/BMEI.2008.107,
author = {Anna Tikhomirov and Anuar Konkashbaev and Dan L. Nicolae},
title = {On Single-Array Genotype Calling Algorithms},
journal ={BioMedical Engineering and Informatics, International Conference on},
volume = {1},
year = {2008},
isbn = {978-0-7695-3118-2},
pages = {459-462},
doi = {http://doi.ieeecomputersociety.org/10.1109/BMEI.2008.107},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - BioMedical Engineering and Informatics, International Conference on
TI - On Single-Array Genotype Calling Algorithms
SN - 978-0-7695-3118-2
SP459
EP462
A1 - Anna Tikhomirov,
A1 - Anuar Konkashbaev,
A1 - Dan L. Nicolae,
PY - 2008
KW - genotype calling algorithm
KW - empirical likelihood
VL - 1
JA - BioMedical Engineering and Informatics, International Conference on
ER -
 
This paper describes issues in using single-array algorithmsfor calling genotypes for Affymetrix arrays, and introduces a computationally efficient procedure that is designed to be used as a complement to the multi-arrays algorithms. The new tool is based on ideas from a previously introduced algorithm with modifications that improve accuracy. These modifications are also necessary for handling the data from the new arrays which have a modified design with no perfect-matches. The main gain in accuracy is obtained from the partitioning of the probes in homogeneous clusters based on measures of efficiency of probe hybridization that are calculated from the probe sequence composition, and based on measures of probe performance that are calculated using a small training dataset.
Index Terms:
genotype calling algorithm, empirical likelihood
Citation:
Anna Tikhomirov, Anuar Konkashbaev, Dan L. Nicolae, "On Single-Array Genotype Calling Algorithms," bmei, vol. 1, pp.459-462, 2008 International Conference on BioMedical Engineering and Informatics, 2008
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