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Fifth IEEE Symposium on Bioinformatics and Bioengineering (BIBE'05)
Feature Selection and Combination Criteria for Improving Predictive Accuracy in Protein Structure Classification
Minneapolis, Minnesota
October 19-October 21
ISBN: 0-7695-2476-1
Chun Yuan Lin, National Tsing Hua University
Ken-Li Lin, National Chiao Tung University and Chung Hua University
Chuen-Der Huang, Hsiuping Institute of Technology
Hsiu-Ming Chang, National Tsing Hua University
Chiao Yun Yang, National Tsing Hua University
Chin-Teng Lin, National Chiao Tung University
Chuan Yi Tang, National Tsing Hua University
D. Frank Hsu, Fordham University
The classification of protein structures is essential for their function determination in bioinformatics. The success of the protein structure classification depends on two factors: the computational methods used and the features selected. In this paper, we use a combinatorial fusion analysis technique to facilitate feature selection and combination for improving predictive accuracy in protein structure classification. When applying these criteria to our previous work, the resulting classification has an overall prediction accuracy rate of 87% for four classes and 69.6% for 27 folding categories. These rates are significantly higher than our previous work and demonstrate that combinatorial fusion is a valuable method for protein structure classification.
Citation:
Chun Yuan Lin, Ken-Li Lin, Chuen-Der Huang, Hsiu-Ming Chang, Chiao Yun Yang, Chin-Teng Lin, Chuan Yi Tang, D. Frank Hsu, "Feature Selection and Combination Criteria for Improving Predictive Accuracy in Protein Structure Classification," bibe, pp.311-315, Fifth IEEE Symposium on Bioinformatics and Bioengineering (BIBE'05), 2005
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