The proliferation of complex and fast-spreading intrusions not only requires advances in intrusion detection mechanisms but also demands development of sophisticated and automated intrusion response systems. In this paper we present a novel cost-sensitive model for intrusion response that incorporates preemptive deployment of the response actions. Specifically, our technique relies on comparing the cost of deploying a response against the cost of damage caused by an "un-attended" intrusion and decides to preemptively deploy a response with maximum benefit. Our technique further allows adaptation of responses to the changing environment through evaluation of success and failure of previously triggered responses. We demonstrate the advantages of the approach and evaluate it using a damage reduction metric.