Data Processing Units (DPUs) in space application as a reconfigurable System-on-Chip solution (SoC) based on a FPGA have been already successfully demonstrated in the Venus Express mission, providing the capability of flexibility and reliability for system design. An enhanced reconfigurable System-on-Chip solution for future space missions also includes the ability to re-program hardware functions even in-flight. The reconfigurable System-on- Chip solution is introduced and the flexibility and reliability of this approach are outlined. Furthermore the requirements for an enhanced SoC design with in-flight reconfigurability for space application are presented.