This manuscript proposes the automatic design and synthesis of nanometer circuits and the optimization of molecular devices by the evolvable hardware technique. The potential of Evolvable Hardware is investigated by means of three different applications: synthesis of molecular electronic circuits, synthesis and optimization of Quantum-dot Cellular Automata (QCA) and the optimization of OLED (Organic Light- Emitting Diodes) parameters. The molecular electronic circuit synthesis is developed using the molecular transistor simulated in SPICE. QCA is a new paradigm used in the development of digital logical circuits, not using the flow of current. This new paradigm allows the development of a new generation of computers, faster and with smaller energy dissipation. Finally, the optimization of OLED parameters is developed using the electrical behavior model of a multi-layer device. In this model, each sub-layer in the emissive layer has a ratio of ETM (Electron Transport Material) and a ratio of HTM (Hole Transport Material). The first results show that the technique is able to synthesize and optimize circuits that perform the logic specified by the user, avoiding noise and other problems that could lead to malfunction. Moreover, the EHW technique is able to optimize the parameters of an organic device, such as OLED.