Comparing the system call sequence of a network application against a sandboxing policy is a popular approach to detecting control-hijacking attack, in which the attacker exploits such software vulnerabilities as buffer overflow to take over the control of a victim application and possibly the underlying machine. The long-standing technical barrier to the acceptance of this system call monitoring approach is how to derive accurate sandboxing policies for Windows applications whose source code is unavailable. In fact, many commercial computer security companies take advantage of this fact and fashion a business model in which their users have to pay a subscription fee to receive periodic updates on the application sandboxing policies, much like anti-virus signatures. This paper describes the design, implementation and evaluation of a sandboxing system called BASS1 that can automatically extract a highly accurate application-specific sandboxing policy from a Win32/X86 binary, and enforce the extracted policy at run time with low performance overhead. BASS is built on a binary interpretation and analysis infrastructure called BIRD, which can handle application binaries with dynamically linked libraries, exception handlers and multi-threading, and has been shown to work correctly for a large number of commercially distributed Windows-based network applications, including IIS and Apache. The throughput and latency penalty of BASS for all the applications we have tested except one is under 8%.