We present a methodology and design flow for signal processing application specific integrated circuit macro-cells. The key features of the methodology are the mastering the complexity of design, the increasing of reuse factor and the early error detection. It takes advantages of a derivative designs, a signal processing modularity, generic modeling and combines both levels of abstraction, in order to produce an efficient architecture. The flow includes a fast verification platform that drives both algorithm and architecture validation in an efficient way. We illustrate the effectiveness of the proposed methodology by a significant industrial application. Experimental design results indicate strong advantages of the proposed schemes.