18th International Parallel and Distributed Processing Symposium (IPDPS'04) - Workshop 9
Parallel RNA Sequence-Structure Alignment
Santa Fe, New Mexico
April 26-April 30
ISBN: 0-7695-2132-0
With the growing number of known RNA genes efficient and accurate computational analysis of RNA sequences is becoming increasingly important. Stochastic context-free grammars (SCFGs) are used as a popular tool to model RNA secondary structures. However, algorithms for aligning an RNA sequence to an SCFG are highly compute-intensive. This has so far limited applications of SCFGs to relatively small problem sizes. In this paper we present the design of a parallel RNA sequence-structure alignment algorithm. Its implementation on a PC cluster leads to significant runtime savings. This makes it possible to compute sequence-structure alignments of even the largest RNAs such as SSU rRNAs and LSU rRNAs in reasonable time.
Citation:
Tong Liu, Bertil Schmidt, "Parallel RNA Sequence-Structure Alignment," ipdps, vol. 10, pp.190b, 18th International Parallel and Distributed Processing Symposium (IPDPS'04) - Workshop 9, 2004