In the field of pattern recognition, multiple classifier systems based on the combination of outputs of a set of different classifiers have been proposed as a method for the development of high performance classification systems. Previous work clearly showed that multiple classifier systems are effective only if the classifiers forming them make independent errors. Therefore, the fundamental need for methods aimed to design “error-independent” classifiers is currently acknowledged. In multiple classifier systems is proposed. Given an initial large set of classifiers, our approach is aimed to select the subset formed by the most error-independent classifiers. Reported results on the classification of multi-sensor remote-sensing images show that this approach allows designing effective multiple classifier systems.