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12th International Conference on Image Analysis and Processing (ICIAP'03)
Toward an Automated System for the Analysis of Cytogenetic Abnormalities Using Fluorescence in situ Hybridization Technique
Mantova, Italy
September 17-September 19
ISBN: 0-7695-1948-2
ASCII Text
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Ezio Catanzariti, Raffaele D. Esposito, Roberta Santilli, Matteo Santoro, "Toward an Automated System for the Analysis of Cytogenetic Abnormalities Using Fluorescence in situ Hybridization Technique," Image Analysis and Processing, International Conference on, pp. 289, 12th International Conference on Image Analysis and Processing (ICIAP'03), 2003.
 
 
BibTex
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@article{ 10.1109/ICIAP.2003.1234065,
author = {Ezio Catanzariti and Raffaele D. Esposito and Roberta Santilli and Matteo Santoro},
title = {Toward an Automated System for the Analysis of Cytogenetic Abnormalities Using Fluorescence in situ Hybridization Technique},
journal ={Image Analysis and Processing, International Conference on},
volume = {0},
year = {2003},
isbn = {0-7695-1948-2},
pages = {289},
doi = {http://doi.ieeecomputersociety.org/10.1109/ICIAP.2003.1234065},
publisher = {IEEE Computer Society},
address = {Los Alamitos, CA, USA},
}
 
 
RefWorks Procite/RefMan/Endnote
x 
 
TY - CONF
JO - Image Analysis and Processing, International Conference on
TI - Toward an Automated System for the Analysis of Cytogenetic Abnormalities Using Fluorescence in situ Hybridization Technique
SN - 0-7695-1948-2
SP
EP
A1 - Ezio Catanzariti,
A1 - Raffaele D. Esposito,
A1 - Roberta Santilli,
A1 - Matteo Santoro,
PY - 2003
KW - null
VL - 0
JA - Image Analysis and Processing, International Conference on
ER -
 
Ezio Catanzariti, University of Naples "Federico II"
Raffaele D. Esposito, University of Naples "Federico II"
Roberta Santilli, University of Naples "Federico II"
Matteo Santoro, University of Naples "Federico II"

In order to build an automatic system that searches, acquires and analyses chromosomal aberrations, we have coupled a commercial system, Metafer4 (MetaSystems, Germany), with an original software (VRAIC) that is able to separate normal from aberrant metaphase images.

Images of metaphases are first stained with a FISH technique and then acquired in three different channels: a BLUE channel, where all chromosomes are stained, a RED channel and a GREEN channel, where only specific pairs of chromosomes are stained.

The analysis takes place in three stages. Images are first segmented in the BLUE channel by an edge detection technique. Edge sets not belonging to chromosomal contours are then eliminated by thresholding techniques. Finally, segmentation obtained in the first stage is used to facilitate detection of chromosomal aberrations in the the RED and GREN channels.

Citation:
Ezio Catanzariti, Raffaele D. Esposito, Roberta Santilli, Matteo Santoro, "Toward an Automated System for the Analysis of Cytogenetic Abnormalities Using Fluorescence in situ Hybridization Technique," iciap, pp.289, 12th International Conference on Image Analysis and Processing (ICIAP'03), 2003
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