A comprehensive and feasible model that delineates the interrelationships between knowledge assets and knowledge creation processes is absent. This study aims to fill this void. Unlike previous research, this study investigates the interrelations among four categories of knowledge assets and four knowledge creation processes — socialization, externalization, combination, and internalization (SECI). In our framework, we argued that different types of knowledge assets may have differing influences on knowledge creation. In order to test the feasibility of this framework, we conducted an empirical research. This study employed a survey instrument to collect data from a wide variety of organizations in manufacturing, trade, transportation and service industries, computer industries, finance, and academic institution. A total of 204 usable responses were analyzed. We identified four inter-relationships from this study. (1) Compared to other knowledge assets, conceptual knowledge assets have a greater effect on externalization of knowledge creation process; (2) Compared to other knowledge assets, routine knowledge assets have a greater effect on socialization of knowledge creation process; (3) Compared to other knowledge assets, experiential knowledge assets do not have a greater effect on internalization of knowledge creation process; and (4) Compared to other knowledge assets, systemic knowledge assets do not have a greater effect on combination of knowledge creation process. The implications of the study are discussed, and further research directions are proposed.