The emergence of e-commerce leads to a fundamental change for the financial industry. The transition into a digital economy produces numerous new opportunities as well as great risks. B2B e-commerce in particular is considered a promising field for the future. As B2B is very closely related to corporate banking, emerging B2B e-commerce business models should constantly be evaluated to see how they fit into the portfolio of current corporate banking activities. This paper provides a framework for a systematic examination of B2B e-commerce business models and their position in the portfolio of corporate banking. The paper indicates that certain business models, like marketplaces, seem to be less attractive despite of huge investments of German banks in this field. However, models combining a bank's core competence with new technology offer a high potential in e-commerce activities.