Component-Based Software Engineering, Separation of Concerns, Model-Driven Architecture, and Aspect-Oriented Programming are four active research areas that have been around for several years now. In this paper, we present how these four paradigms can be put together in the context of a new software development method and we show how they can complement each other at different stages in the development life-cycle of enterprise, middleware-mediated applications. Different software development methods, such as Fondue, Catalysis, KobrA, and the Rational Unified Process, are also analyzed, pointing out their differences and limitations. In the end, requirements for a dedicated tool infrastructure that would support the new development approach are discussed.