The design of clock distribution networks in synchronous digital systems presents enormous challenges. Controlling the clock signal delay in the presence of various noise sources, process parameter variations, and environmental effects represents a fundamental problem in the design of high speed synchronous circuits. A polynomial time algorithm that improves the tolerance of a clock distribution network to process and environmental variations is presented in this paper. The algorithm generates a clock tree topology that minimizes the uncertainty of the clock signal delay to the most critical data paths. Strategies for enhancing the physical layout of the clock tree to decrease delay uncertainty are also presented. Application of the methodology on benchmark circuits demonstrates clock tree topologies with decreased delay uncertainties of up to 90%. Techniques to enhance a clock tree layout have been applied on a set of benchmark circuits, yielding a reduction in delay uncertainty of up to 48%.