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2004 IEEE Computational Systems Bioinformatics Conference (CSB'04)
Stanford, California
August 16-August 19
ISBN: 0-7695-2194-0
Catalin Barbacioru, Ohio State University
Daniel J. Cowden, Ohio State University
Joel Saltz, Ohio State University
This paper presents an efficient algorithm, of polynomial complexity for learning Bayesian belief networks over a dataset of gene expression levels. Given a dataset that is large enough, the algorithm generates a belief network close to the underlying model by recovering the Markov blanket of every node. The time complexity is dependent on the connectivity of the generating graph and not on the size of it, and therefore yields to exponential savings in computational time relative to some previously known algorithms. We use bootstrap and permutation techniques in order to measure confidence in our finding. To evaluate this algorithm, we present experimental results on S.cerevisiae cellcycle mesurements of Spellman et al. (1998) [5].
Citation:
Catalin Barbacioru, Daniel J. Cowden, Joel Saltz, "An Algorithm for Reconstruction of Markov Blankets in Bayesian Networks of Gene Expression Datasets," csb, pp.628-629, 2004 IEEE Computational Systems Bioinformatics Conference (CSB'04), 2004
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