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2004 IEEE Computational Systems Bioinformatics Conference (CSB'04)
Stanford, California
August 16-August 19
ISBN: 0-7695-2194-0
Jean-Loup Faulon, Sandia National Laboratories
Shawn Martin, Sandia National Laboratories
Robert D. Carr, Sandia National Laboratories
We investigate the robustness of biological networks, emphasizing gene regulatory networks. We define the robustness of a dynamical network as the magnitude of perturbation in terms of rates and concentrations that will not change the steady state dynamics of the network. We find the number of dynamical networks versus their dynamical robustness follows a power law. We observe module robustness to increase with node degree in published gene regulatory networks. Finally, based on dynamical robustness, we propose a growth model for producing networks with power law degree distibutions.
Citation:
Jean-Loup Faulon, Shawn Martin, Robert D. Carr, "Dynamical Robustness in Gene Regulatory Networks," csb, pp.626-627, 2004 IEEE Computational Systems Bioinformatics Conference (CSB'04), 2004
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