loading...
 This Article 
   
 Share 
   
 Bibliographic References 
   
 Add to: 
 
Digg
Furl
Spurl
Blink
Simpy
Google
Del.icio.us
Y!MyWeb
 
 Search 
   
IEEE Computer Society Bioinformatics Conference (CSB'03)
Identifying Regulatory Signals in DNA-Sequences with a Non-statistical Approximation Approach
Stanford, California
August 11-August 14
ISBN: 0-7695-2000-6
Cun-Quan Zhang, West Virginia University
Yunkai Liu, West Virginia University
Elaine M. Eschen, West Virginia University
Keqiang Wu, West Virginia University
The identification of regulatory signals is one of the most challenging tasks in bioinformatics. The development of gene-profiling technologies now makes it possible to obtain vast data on gene expression in a particular organism under various conditions. This has created the opportunity to identify and analyze the parts of the genome believed to be responsible for transcription control - the transcription factor DNA-binding motifs (TFBMs). Developing a practical and efficient computational tool to identify TFBMs will enable us to better understand the interplay among thousands of genes in a complex eukaryotic organism. This problem, which is mathematically formulated as the motif finding problem in computer science, has been studied extensively in recent years. We develop a new mathematical model and approximation technique for motif searching. Based on the graph theoretic and geometric properties of this approach, we propose a non-statistical approximation algorithm to find motifs in a set of genome sequences.
Citation:
Cun-Quan Zhang, Yunkai Liu, Elaine M. Eschen, Keqiang Wu, "Identifying Regulatory Signals in DNA-Sequences with a Non-statistical Approximation Approach," csb, pp.593, IEEE Computer Society Bioinformatics Conference (CSB'03), 2003
Usage of this product signifies your acceptance of the Terms of Use.